HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Ethyl 2-chloro-2-(2-fluorobenzoyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Ethyl 3-(2-fluorophenyl)-3-oxopropanoate | HCID 296342 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 2-chloro-2-(2-fluorobenzoyl)acetate | HCID 18473854 | 97.2% |
Reaction Steps
Using ethyl 3-(2-fluorophenyl)-3-oxopropanoate (1.0 g, 4.75 mmol), sulfuryl chloride (771 mg, 5.7 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20-B (i), the title compound (1.13 g, 97%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139589B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-9ce64de50760429caf0177a60c20e3e3 |
| Source note | uspto-grants-2015_09 |