Sulfuryl chloride → Ethyl 2-chloro-3-(2-methoxyphenyl)-3-oxopropanoate

HRID 2282186Notes

Reaction equation

HRID 2282186 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].S(Cl)([Cl:20])(=O)=O>C(OCC)C>[Cl:20][CH:10]([C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 2759695Ethyl (2-methoxybenzoyl)acetate

Product 1

HCID 54152211Ethyl 2-chloro-3-(2-methoxyphenyl)-3-oxopropanoateYield 97%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-methoxyphenyl)-3-oxopropanoate (1.7 g, 7.4 mmol), sulfuryl chloride (1.2 g, 8.9 mmol) and diethyl ether (100 mL) as starting materials and in the same manner as in Example 20(i), the title compound (1.8 g, 97%) was obtained as colorless oil.

Sources & evidence

ORD record
ord-5af26e72920045898202ee7fd6076789
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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