Hydrochloric Acid → HCID 178433760, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-methyl-4-{2-[(2-methyl-3-{4-phenyl-5-[1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazol-3-yl]-1,3-thiazol-2-yl}pyrazolo[1,5-a]pyridin-5-yl)oxy]ethyl}piperazin-2-one obtained above in THF (6 mL) and MeOH (2 mL), was added 2M hydrochloric acid (2 mL) and the mixture was stirred for 1 h at 60° C. To the mixture was added EtOAc (5 mL) and the resulting precipitate has been collected by filtration to obtain title compound (217 mg, 87%) as a yellow solid.

Provenance & Evidence