Hydrochloric Acid → HCID 178433760, compound

HRID 2282244Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]3[N:17]=[C:18]([CH3:42])[C:19]([C:20]4[S:21][C:22]([C:31]5[N:35]=[CH:34][N:33](C6CCCCO6)[N:32]=5)=[C:23]([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[N:24]=4)=[C:13]3[CH:12]=2)[CH2:4][C:3]1=[O:43].[ClH:44].CCOC(C)=O>C1COCC1.CO>[ClH:44].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]3[N:17]=[C:18]([CH3:42])[C:19]([C:20]4[S:21][C:22]([C:31]5[N:35]=[CH:34][NH:33][N:32]=5)=[C:23]([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[N:24]=4)=[C:13]3[CH:12]=2)[CH2:4][C:3]1=[O:43]

Participants

Conditions

Temperature: 60 °C

Procedure

To a suspension of 1-methyl-4-{2-[(2-methyl-3-{4-phenyl-5-[1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazol-3-yl]-1,3-thiazol-2-yl}pyrazolo[1,5-a]pyridin-5-yl)oxy]ethyl}piperazin-2-one obtained above in THF (6 mL) and MeOH (2 mL), was added 2M hydrochloric acid (2 mL) and the mixture was stirred for 1 h at 60° C. To the mixture was added EtOAc (5 mL) and the resulting precipitate has been collected by filtration to obtain title compound (217 mg, 87%) as a yellow solid.

Workup

filtrationthe resulting precipitate has been collected by filtration

Sources & evidence

ORD record: ord-717f84de111b40ea93ec27448307e3f1
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139589B2

Reaction notes

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