HCID 58095051, compound → HCID 58095099, compound

HRID 2282335Notes

Reaction equation

HRID 2282335 reaction equation
C([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[S:10][C:11]([Sn](CCCC)(CCCC)CCCC)=[CH:12][C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[Cl:21])C=C.I[C:36]1[CH:41]=[CH:40][N:39]=[C:38]2[NH:42][C:43](=[O:45])[O:44][C:37]=12>>[Cl:21][C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[C:13]1[CH:12]=[C:11]([C:36]2[CH:41]=[CH:40][N:39]=[C:38]3[NH:42][C:43](=[O:45])[O:44][C:37]=23)[S:10][C:9]=1[C:5]1[NH:4][CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 58095051HCID 58095051, compoundHCID 58095108HCID 58095108, compound

Product 1

HCID 58095099HCID 58095099, compound

Procedure

The title compound was prepared from 1-allyl-2-[3-(2,4-dichlorophenyl)-5-(tributylstannyl)-2-thienyl]-1H-imidazole and 7-iodo[1,3]oxazolo[4,5-b]pyridin-2(3H)-one using procedures analogous to those described in Example 8-A, Steps 2 and 3. LC/MS (AA) ES+ 429, 431. 1H NMR (400 MHz, d6 DMSO) δ: 8.03 (d, J=5.77 Hz, 1H), 7.83 (s, 1H), 7.59 (d, J=2.01 Hz, 1H), 7.43-7.39 (m, 2H), 7.36 (d, J=8.29 Hz, 1H), 7.06 (s, 2H).

Sources & evidence

ORD record
ord-a69dd11c00d749f59dc2d9bfdf170d4f
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

Loading…