Thionyl Chloride → 4-Bromo-3-methylbenzoyl chloride

HRID 2282336Notes

Reaction equation

HRID 2282336 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[CH3:11].S(Cl)([Cl:14])=O>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 821314-Bromo-3-methylbenzoic acid

Product 1

HCID 70215344-Bromo-3-methylbenzoyl chloride

Procedure

A mixture of 4-bromo-3-methylbenzoic acid (5.0 g, 23.25 mmol) and thionylchloride (50 ml) was refluxed for 5 hours. After removal of thionyl chloride, the residue was dried under high vacuum and used in next step without further purification.

Workup

  1. temperaturewas refluxed for 5 hours
  2. customAfter removal of thionyl chloride
  3. customthe residue was dried under high vacuum
  4. customused in next step without further purification

Sources & evidence

ORD record
ord-7cc23eb2edb742289ea6d1eea8982600
Source dataset
uspto-grants-2015_09
Patent number
US09139868B2

Reaction notes

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