Hydrochloric Acid → HCID 131731852, compound

HRID 2282855Notes

Reaction equation

HRID 2282855 reaction equation
C([NH:4][CH:5]([CH:9]1[CH2:16][C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:6]([OH:8])=[O:7])(=O)C.[ClH:17]>>[ClH:17].[NH2:4][CH:5]([CH:9]1[CH2:16][C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 89572991HCID 89572991, compound

Product 1

HCID 131731852HCID 131731852, compoundYield 100.1%

Procedure

A mixture of #100 (200 mg, 0.912 mmol, 1 eq.) and 6 N aqueous hydrochloric acid (12.3 mL, 73.8 mmol, 81 eq.) was heated at reflux overnight. The reaction mixture was concentrated in vacuo to give the single enantiomer #101 (195 mg) as an off-yellow solid, which was used in the next step without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-e1f99dcb6c0c4b079911d0d508b2214e
Source dataset
uspto-grants-2015_09
Patent number
US09138486B2

Reaction notes

Loading…