Diisopropylethylamine → HCID 89573170, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	HCID 69019103	HCID 69019103	—
Reactant	N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-5-methyl-1-oxo-1-(pentafluorophenoxy)heptan-4-yl]-N-methyl-L-valinamide	HCID 86685740	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 89573170	HCID 89573170	83%

Reaction Steps

To a mixture of #104 (2.00 g, <2.58 mmol, 1 eq.) in dichloromethane (6 mL, 0.4 M) was added a solution of #103 (483 mg, 2.16 mmol, 1 eq.) in dichloromethane (2 mL) followed by diisopropylethylamine (1.35 mL, 7.73 mmol, 3 eq.). The reaction mixture was stirred for 16 hours, then adsorbed onto silica and purified by silica gel chromatography (Gradient: 0% to 20% methanol in dichloromethane) to give #105 (1.67 g, 83%) as a white foam. Fractions containing the desired product with impurities (0.571 g) were collected separately.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09138486B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-299cfe968d5b4ad8b668ea1a0e1cd5b9
Source note	uspto-grants-2015_09