Hydrochloric Acid → HCID 86718850, compound

HRID 2283152Notes

Reaction equation

HRID 2283152 reaction equation
[OH-].[K+].[F:3][C:4]([F:39])([O:28][C:29]1[CH:38]=[CH:37][C:32]([C:33]([O:35]C)=[O:34])=[CH:31][CH:30]=1)[CH:5]([F:27])[O:6][C:7]([F:26])([F:25])[C:8]([F:24])([O:13][C:14]([F:23])([F:22])[C:15]([F:21])([F:20])[C:16]([F:19])([F:18])[F:17])[C:9]([F:12])([F:11])[F:10].Cl>O>[F:3][C:4]([F:39])([O:28][C:29]1[CH:38]=[CH:37][C:32]([C:33]([OH:35])=[O:34])=[CH:31][CH:30]=1)[CH:5]([F:27])[O:6][C:7]([F:26])([F:25])[C:8]([F:24])([O:13][C:14]([F:22])([F:23])[C:15]([F:21])([F:20])[C:16]([F:18])([F:17])[F:19])[C:9]([F:12])([F:11])[F:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86718849HCID 86718849, compound

Product 1

HCID 86718850HCID 86718850, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Water (500.0 mL) and potassium hydroxide were added to a round bottom flask equipped with a stirrer. Methyl 4-(1,1,2-trifluoro-2-(1,1,2,3,3,3-hexafluoro-2-(perfluoropropoxy)propoxy)ethoxy)benzoate (50.0 g, 0.0856 mol), as prepared in Example 11, was then added via the addition funnel and the reaction was placed in an oil bath and heated to a gentle reflux overnight. The flask was allowed to cool before acidifying with concentrated HCl, down to ph˜1.0. The precipitate was filtered and dried overnight. The solids were analyzed by proton NMR to be 4-(1,1,2-trifluoro-2-(1,1,2,3,3,3-hexafluoro-2-(perfluoropropoxy)propoxy)ethoxy)benzoic acid.

Workup

  1. customequipped with a stirrer
  2. additionwas then added via the addition funnel
  3. customthe reaction was placed in an oil bath
  4. temperatureheated to
  5. temperaturea gentle reflux overnight
  6. temperatureto cool
  7. filtrationThe precipitate was filtered
  8. customdried overnight

Sources & evidence

ORD record
ord-27f449ced17d4c2f84ca5df53e6e941a
Source dataset
uspto-grants-2015_09
Patent number
US09145356B2

Reaction notes

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