HCID 43532198, compound → HCID 42646992, compound

HRID 2283277Notes

Reaction equation

HRID 2283277 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[C:13]1([C:19]2[CH:24]=[CH:23][C:22](/[CH:25]=[CH:26]/[S:27](Cl)(=[O:29])=[O:28])=[CH:21][CH:20]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>N1C=CC=CC=1>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][S:27](/[CH:26]=[CH:25]/[C:22]2[CH:23]=[CH:24][C:19]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:20][CH:21]=2)(=[O:29])=[O:28])[C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 43532198HCID 43532198, compoundHCID 457926442-AMino-6-fluorobenzenesulfonaMide

Product 1

HCID 42646992HCID 42646992, compoundYield 19.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-6-fluoro-benzenesulfonamide (38 mg, 200 μmol) and (E)-2-(4-phenylphenyl)ethenesulfonyl chloride (56 mg, 200 μmol) were dissolved in pyridine (1.5 mL) and the reaction mixture was shaken for 12 h. The solvent was removed in vacuum and the residues were purified by HPLC to give the product (16.6 mg, 19%).

Workup

  1. customThe solvent was removed in vacuum
  2. customthe residues were purified by HPLC

Sources & evidence

ORD record
ord-e8cd8a2e4883498cbe6466480cee763b
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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