2-Aminobenzenesulfonamide → HCID 57751043, compound

HRID 2283294Notes

Reaction equation

HRID 2283294 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[Cl:12][C:13]1[C:14]([F:23])=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>N1C=CC=CC=1>[Cl:12][C:13]1[C:14]([F:23])=[C:15]([S:19]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8](=[O:9])(=[O:10])[NH2:11])(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 728942-AminobenzenesulfonamideHCID 27783213-Chloro-2-fluorobenzenesulfonyl Chloride

Product 1

HCID 57751043HCID 57751043, compoundYield 19.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Aminobenzenesulfonamide (54 mg, 0.31 mmol) and 3-chloro-2-fluoro-benzenesulfonyl chloride (47 mg, 0.21 mmol) were dissolved in pyridine (1 ml) and the reaction mixture was stirred for 12 h. The solvent was removed in vacuo and the residue was purified by HPLC to give the product (15 mg, 19%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-cf6a9bc99715492e95210d879f244b70
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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