2-Amino-5-cyanobenzene-1-sulfonamide → (E)-2-(2-(4-Chloro-2-methoxyphenyl)vinylsulfonamido)-5-cyanobenzenesulfonamide

HRID 2283320Notes

Reaction equation

HRID 2283320 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]=[CH:22][S:23](Cl)(=[O:25])=[O:24])=[C:17]([O:27][CH3:28])[CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[S:23]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][C:3]=2[S:10]([NH2:13])(=[O:11])=[O:12])(=[O:24])=[O:25])=[C:17]([O:27][CH3:28])[CH:16]=1

Participants

3

Reactant 2

HCID 223239942-Amino-5-cyanobenzene-1-sulfonamideHCID 739930052-(4-Chloro-2-methoxyphenyl)-ethenesulfonyl chloride

Product 1

HCID 57750921(E)-2-(2-(4-Chloro-2-methoxyphenyl)vinylsulfonamido)-5-cyanobenzenesulfonamideYield 27%

Procedure

The title compound was synthesized as described for Example 178 in 27% yield, starting from 2-amino-5-cyanobenzenesulfonamide and 2-(4-chloro-2-methoxy-phenyl)-ethenesulfonyl chloride.

Sources & evidence

ORD record
ord-1d4cb220e6534dcd81749710e6e1676d
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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