3,3-Dimethyl-1-butyne → HCID 57751060, compound

HRID 2283325Notes

Reaction equation

HRID 2283325 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[CH3:24][C:25]([CH3:29])([CH3:28])[C:26]#[CH:27]>>[CH3:24][C:25]([CH3:29])([CH3:28])[C:26]#[C:27][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 135123,3-Dimethyl-1-butyneHCID 57750959HCID 57750959, compound

Product 1

HCID 57751060HCID 57751060, compoundYield 34%

Procedure

The title compound was synthesized as described for Example 179 a) in 34% yield, starting from 2-(2-(6-bromopyridin-3-yl)ethylsulfonamido)benzenesulfonamide and 3,3-dimethyl-1-butyne. Purification by column chromatography, using 10 to 60% ethyl acetate in heptane as the eluent.

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-4b608d48ac31428fb5b5584fb80a5242
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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