2-Aminobenzenesulfonamide → HCID 57750970, compound

HRID 2283326Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[Br:12][C:13]1[N:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[S:21](Cl)(=[O:23])=[O:22])=[CH:15][CH:14]=1>>[Br:12][C:13]1[N:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[S:21]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8]([NH2:11])(=[O:9])=[O:10])(=[O:23])=[O:22])=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 728942-Aminobenzenesulfonamide

HCID 57751050HCID 57751050, compound

Product 1

HCID 57750970HCID 57750970, compoundYield 69%

Procedure

The title compound was synthesized as described for Example 178 in 69% yield, starting from 2-aminobenzenesulfonamide and (E)-2-(6-bromopyridin-3-yl)ethenesulfonyl chloride. Purification by column chromatography, using ammonium hydroxide/methanol/chloroform (1:10:89) as the eluent.

Workup

customPurification by column chromatography

Sources & evidence

ORD record: ord-0959ecb9c375459ebf59189c034fc80e
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09145380B2

Reaction notes

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