Ethynylcyclohexane → HCID 57751015, compound

HRID 2283329Notes

Reaction equation

HRID 2283329 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[CH:24]1([C:30]#[CH:31])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([C:30]#[C:31][C:2]2[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 70263EthynylcyclohexaneHCID 57750959HCID 57750959, compound

Product 1

HCID 57751015HCID 57751015, compoundYield 25%

Procedure

The title compound was synthesized as described for Example 179 a) in 25% yield, starting from 2-(2-(6-bromopyridin-3-yl)ethylsulfonamido)benzenesulfonamide and cyclohexylacetylene. Purification by column chromatography using a gradient of 10-60% ethyl acetate in heptane as the eluent.

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-11aec5bca703445b94b4ce0450f4bc29
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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