反应详情

温度

180 °C

Sodium acetate (64 mg, 0.78 mmol) and para-toluenesulfonhydrazide (145 mg, 0.78 mmol) was added to a solution of (E)-5-chloro-2-(2-(4-chloro-2-methoxyphenyl)vinylsulfonamido)benzenesulfonamide (85 mg, 0.19 mmol) in tetrahydrofuran (3 mL). The reaction mixture was heated at 180° C. for 15 min in a microwave reactor. The solids were removed by filtration, washed with tetrahydrofuran and the combined filtrates were evaporated. Purification by preparative HPLC gave 0.037 g (43% yield) of the title compound.

1. customThe solids were removed by filtration
2. washwashed with tetrahydrofuran
3. customthe combined filtrates were evaporated
4. customPurification by preparative HPLC