HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methylbenzenesulfonamide → (E)-2-(2-(4-Chloro-2-methoxyphenyl)vinylsulfonamido)-4-methylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methylbenzenesulfonamide | HCID 11436538 | — |
| Reactant | (E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride | HCID 22711054 | — |
| Product | (E)-2-(2-(4-Chloro-2-methoxyphenyl)vinylsulfonamido)-4-methylbenzenesulfonamide | HCID 57750912 | 69% |
Reaction Steps
The title compound was synthesized as described for Example 194 a) in 69% yield, starting from 2-amino-4-methylbenzenesulfonamide and (E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride (1.5 equiv.). Purification by column chromatography, using chloroform/methanol (95:5) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145380B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1d0613668a3a4cd3bf37e921ba4566bb |
| Source note | uspto-grants-2015_09 |