反应详情

温度

100 °C

A solution of N,N-diallyl-4-(3-(5-chloro-6-methoxypyridin-3-yl)phenylsulfonamido)pyridine-3-sulfonamide (0.19 g, 0.36 mmol) in dichloromethane (5 mL) was added to tetrakis(triphenylphosphine)palladium(0) (0.021 g, 0.022 mmol) and 1,3-dimethylbarbituric acid (0.336 g, 2.15 mmol) under an atmosphere of argon. The reaction was heated at 100° C. for 15 min in a microwave reactor and the reaction mixture was concentrated. Purification by column chromatography, using chloroform/methanol (95:5-9:1) as the eluent, gave the title compound in 49% yield.

1. concentrationthe reaction mixture was concentrated
2. customPurification by column chromatography