2-Amino-5-methylbenzenesulfonamide → 2-[2-(4-Chloro-2-methoxy-phenyl)-ethenesulfonylamino]-5-methyl-benzenesulfonamide

HRID 2283348Notes

Reaction equation

HRID 2283348 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[Cl:13][C:14]1[CH:19]=[CH:18][C:17](/[CH:20]=[CH:21]/[S:22](Cl)(=[O:24])=[O:23])=[C:16]([O:26][CH3:27])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]=[CH:21][S:22]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=2[S:9]([NH2:12])(=[O:10])=[O:11])(=[O:23])=[O:24])=[C:16]([O:26][CH3:27])[CH:15]=1

Participants

3

Reactant 2

HCID 2455842-Amino-5-methylbenzenesulfonamideHCID 22711054(E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride

Product 1

HCID 687826342-[2-(4-Chloro-2-methoxy-phenyl)-ethenesulfonylamino]-5-methyl-benzenesulfonamideYield 81%

Procedure

The title compound was synthesized as described for Example 194 a) in 81% yield, starting from 2-amino-5-methylbenzenesulfonamide and (E)-2-(4-chloro-2-methoxyphenyl)ethenesulfonyl chloride (1 equiv.).

Sources & evidence

ORD record
ord-d358716c455d49b8b3a1a7553e065d93
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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