3,3-Dimethyl-1-butyne → HCID 57750930, compound

HRID 2283364Notes

Reaction equation

HRID 2283364 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:18]=[CH:17][S:16][C:15]=2[S:19]([NH2:22])(=[O:21])=[O:20])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[CH3:23][C:24]([CH3:28])([CH3:27])[C:25]#[CH:26]>>[CH3:23][C:24]([CH3:28])([CH3:27])[C:25]#[C:26][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:18]=[CH:17][S:16][C:15]=2[S:19]([NH2:22])(=[O:21])=[O:20])(=[O:12])=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 135123,3-Dimethyl-1-butyneHCID 57750944HCID 57750944, compound

Product 1

HCID 57750930HCID 57750930, compoundYield 18%

Procedure

The title compound was synthesized as described for Example 210 in 18% yield, starting from 3-[2-(4-bromo-phenyl)-ethanesulfonylamino]-thiophene-2-sulfonic acid amide and 3,3-dimethyl-1-butyne. Purification by column chromatography, using 50% ethyl acetate in hexanes as the eluent, followed by purification by preparative HPLC.

Workup

  1. customPurification by column chromatography
  2. customfollowed by purification by preparative HPLC

Sources & evidence

ORD record
ord-78ee4dfebcb048c18efe9b00a43af496
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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