(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride → (E)-5-Chloro-2-(2-(4-chlorophenyl)vinylsulfonamido)-4-fluorobenzene sulfonamide

HRID 2283376Notes

Reaction equation

HRID 2283376 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([Cl:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[S:23](Cl)(=[O:25])=[O:24])=[CH:17][CH:16]=1>>[Cl:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([NH:1][S:23](/[CH:22]=[CH:21]/[C:18]2[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=2)(=[O:24])=[O:25])=[C:3]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:4]=1

Participants

3

Reactant 2

HCID 5938154(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chlorideHCID 231042282-Amino-5-chloro-4-fluorobenzenesulfonamide

Product 1

HCID 57751076(E)-5-Chloro-2-(2-(4-chlorophenyl)vinylsulfonamido)-4-fluorobenzene sulfonamideYield 61%

Procedure

The title compound was synthesized as described for 226 a) in 61% yield, starting from 2-amino-5-chloro-4-fluorobenzenesulfonamide and (E)-2-(4-chlorophenyl)ethenesulfonyl chloride.

Sources & evidence

ORD record
ord-2485d03d1a3e40a0876fb68bf4269a8b
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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