1-Ethynyl-4-(trifluoromethyl)benzene → HCID 59635822, compound

HRID 2283380Notes

Reaction equation

HRID 2283380 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=1.[C:24]([C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=1)#[CH:25]>>[F:33][C:32]([F:34])([F:35])[C:29]1[CH:28]=[CH:27][C:26]([C:24]#[C:25][C:2]2[N:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[S:20]([NH2:23])(=[O:22])=[O:21])(=[O:12])=[O:11])=[CH:4][CH:3]=2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 43482951-Ethynyl-4-(trifluoromethyl)benzeneHCID 57750959HCID 57750959, compound

Product 1

HCID 59635822HCID 59635822, compoundYield 28%

Procedure

The title compound was synthesized as described for Example 179 a) in 28% yield, starting from 2-(2-(6-bromopyridin-3-yl)ethylsulfonamido)benzenesulfonamide and 4-ethynyl-alpha,alpha,alpha-trifluorotoluene. Purification by preparative HPLC.

Workup

  1. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-252fb401c41744418f31fe3d7bab0043
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

Loading…