HCID 22316709, compound → 4-(Methanesulfonyl)-2-methoxyaniline

HRID 2283510Notes

Reaction equation

HRID 2283510 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:4]=1[N+:13]([O-])=O>[Pd].C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:4]=1[NH2:13]

Participants

4

Reactant 1

HCID 22316709HCID 22316709, compound

Product 1

HCID 223167854-(Methanesulfonyl)-2-methoxyanilineYield 98.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 2-methoxy-4-(methylsulfonyl)-1-nitrobenzene (0.175 g, 0.76 mmol) and palladium on carbon (10 wt %, 0.10 g) in ethanol (10 mL) was stirred under hydrogen at one atmosphere pressure for 18 hours. The reaction was filtered through celite and concentrated to give 2-methoxy-4-(methylsulfonyl)aniline (0.15 g, 92%).

Workup

  1. filtrationThe reaction was filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d37c5a4e6ec54e1290828c6f846fdbcb
Source dataset
uspto-grants-2015_09
Patent number
US09145402B2

Reaction notes

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