p-Toluenesulfonic acid → HCID 86682361, compound

HRID 2283610Notes

Reaction equation

HRID 2283610 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:12][C:13]1[C:14]([O:29][C:30]2[CH:35]=[C:34]([C:36]([F:39])([F:38])[F:37])[C:33]([F:40])=[CH:32][C:31]=2[C:41]2[CH:46]=[CH:45][N:44]=[N:43][CH:42]=2)=[CH:15][C:16]([F:28])=[C:17]([S:19]([NH:22][C:23]2[N:24]=[CH:25][S:26][CH:27]=2)(=[O:21])=[O:20])[CH:18]=1>CC(C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:6][CH:7]=1.[Cl:12][C:13]1[C:14]([O:29][C:30]2[CH:35]=[C:34]([C:36]([F:37])([F:39])[F:38])[C:33]([F:40])=[CH:32][C:31]=2[C:41]2[CH:46]=[CH:45][N:44]=[N:43][CH:42]=2)=[CH:15][C:16]([F:28])=[C:17]([S:19]([NH:22][C:23]2[N:24]=[CH:25][S:26][CH:27]=2)(=[O:21])=[O:20])[CH:18]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 56598750HCID 56598750, compound

Product 1

HCID 86682361HCID 86682361, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 4-methylbenzenesulfonic acid (0.489 g, 2.84 mmol) in acetone (6 mL) was added to a solution of 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide (1.56 g, 2.84 mmol) in acetone. The solution was stirred for 15 min, filtered, and concentrated in vacuo to give title compound as a tan foam which was used without further purification.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-10d85b5017844138a78d32879dc034a3
Source dataset
uspto-grants-2015_09
Patent number
US09145407B2

Reaction notes

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