Hydrochloric Acid → HCID 86682362, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-N-(ethoxymethyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide (Preparation 15, 67 mg, 0.12 mmol) in methanol (1 mL) was added a 2.0 M solution of hydrogen chloride in water (1 mL, 2.00 mmol). The reaction mixture was heated at 60° C. for 6 hours then concentrated in vacuo. The residue was freeze dried from acetonitrile-water to afford the title compound as a white solid (69 mg).

Provenance & Evidence