Hydrochloric Acid → HCID 86682362, compound

HRID 2283611Notes

Reaction equation

HRID 2283611 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:9]=2[O:10][C:11]2[C:16]([Cl:17])=[CH:15][C:14]([S:18]([N:21](COCC)[C:22]3[N:27]=[CH:26][C:25]([F:28])=[CH:24][N:23]=3)(=[O:20])=[O:19])=[C:13]([F:33])[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[ClH:39].O>CO>[ClH:17].[ClH:39].[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:9]=2[O:10][C:11]2[C:16]([Cl:17])=[CH:15][C:14]([S:18]([NH:21][C:22]3[N:23]=[CH:24][C:25]([F:28])=[CH:26][N:27]=3)(=[O:20])=[O:19])=[C:13]([F:33])[CH:12]=2)[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 66652495HCID 66652495, compound

Product 1

HCID 86682362HCID 86682362, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-N-(ethoxymethyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide (Preparation 15, 67 mg, 0.12 mmol) in methanol (1 mL) was added a 2.0 M solution of hydrogen chloride in water (1 mL, 2.00 mmol). The reaction mixture was heated at 60° C. for 6 hours then concentrated in vacuo. The residue was freeze dried from acetonitrile-water to afford the title compound as a white solid (69 mg).

Workup

  1. concentrationthen concentrated in vacuo
  2. dry with materialdried from acetonitrile-water

Sources & evidence

ORD record
ord-a21a78233ef140b6b1be33246dcbc1d8
Source dataset
uspto-grants-2015_09
Patent number
US09145407B2

Reaction notes

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