Glyoxylic Acid → HCID 68047230, compound

HRID 2283654Notes

Reaction equation

HRID 2283654 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([O:13][CH3:14])=[C:7]([CH2:9][C:10](=[O:12])[CH3:11])[CH:8]=1.[C:17]([OH:21])(=[O:20])[CH:18]=O>>[OH:12][C:10]1([CH3:11])[O:21][C:17](=[O:20])[CH:18]=[C:9]1[C:7]1[CH:8]=[C:3]([C:2]([F:15])([F:16])[F:1])[CH:4]=[CH:5][C:6]=1[O:13][CH3:14]

Participants

3

Reactant 2

HCID 760Glyoxylic AcidHCID 846953521-[2-Methoxy-5-(trifluoromethyl)phenyl]-2-propanone

Product 1

HCID 68047230HCID 68047230, compoundYield 101.2%

Conditions

Temperature
100 °C

Procedure

5-(Trifluoromethyl)-2-methoxyphenylacetone (2800 mg, 12 mmol) was mixed with glyoxylic acid (2.7 mL 18 mmol) and stirred at 100° C. for 16 hours. The reaction mixture was then concentrated in vacuo and azeotroped with toluene to afford the title compound (3.5 g).

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customazeotroped with toluene

Sources & evidence

ORD record
ord-d6ffa2db25ee49ce898092ab539e07f8
Source dataset
uspto-grants-2015_09
Patent number
US09145407B2

Reaction notes

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