Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | 1-[2-Methoxy-5-(trifluoromethyl)phenyl]propan-2-one | HCID 84695352 | — |
| Product | HCID 68047230 | HCID 68047230 | 101.2% |
Reaction Steps
5-(Trifluoromethyl)-2-methoxyphenylacetone (2800 mg, 12 mmol) was mixed with glyoxylic acid (2.7 mL 18 mmol) and stirred at 100° C. for 16 hours. The reaction mixture was then concentrated in vacuo and azeotroped with toluene to afford the title compound (3.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09145407B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-d6ffa2db25ee49ce898092ab539e07f8 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
