Ammonia methanol → HCID 90308806, compound

HRID 2283662Notes

Reaction equation

HRID 2283662 reaction equation
[NH3:1].CO.[CH3:4][S:5][C:6]1[N:7]=[N:8][C:9]([C:23]([O:25]CC)=O)=[C:10]([NH:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[CH:18][CH:17]=[CH:16]3)[N:11]=1>C1COCC1>[CH3:4][S:5][C:6]1[N:7]=[N:8][C:9]([C:23]([NH2:1])=[O:25])=[C:10]([NH:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[CH:18][CH:17]=[CH:16]3)[N:11]=1

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 90308938HCID 90308938, compound

Product 1

HCID 90308806HCID 90308806, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
130 °C

Procedure

A 2 M ammonia-methanol solution (3 ml) was added to a solution of ethyl 3-(methylthio)-5-(quinolin-6-ylamino)-1,2,4-triazine-6-carboxylate obtained in the above-described Step 1 (150 mg) in THF (0.5 ml), and then the reaction solution was stirred in a microwave reactor at 130° C. for 30 minutes. The precipitate was filtrated to obtain 3-(methylthio)-5-(quinolin-6-ylamino)-1,2,4-triazine-6-carboxamide as a crude white solid.

Workup

  1. filtrationThe precipitate was filtrated

Sources & evidence

ORD record
ord-f2aaa78fc9354a54ac1c77244d2e82eb
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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