m-Chloroperbenzoic acid → HCID 90308749, compound

HRID 2283679Notes

Reaction equation

HRID 2283679 reaction equation
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[C:12]([C:15]1[S:19][C:18]([C:20]2[CH:21]=[C:22]([NH:26][C:27]3[N:28]=[C:29]([NH:36][C@@H:37]4[CH2:42][CH2:41][CH2:40][CH2:39][C@@H:38]4[NH2:43])[N:30]=[N:31][C:32]=3[C:33]([NH2:35])=[O:34])[CH:23]=[N:24][CH:25]=2)=[CH:17][CH:16]=1)(=[O:14])[CH3:13]>>[C:12]([C:15]1[S:19][C:18]([C:20]2[CH:25]=[N+:24]([O-:9])[CH:23]=[C:22]([NH:26][C:27]3[N:28]=[C:29]([NH:36][C@@H:37]4[CH2:42][CH2:41][CH2:40][CH2:39][C@@H:38]4[NH2:43])[N:30]=[N:31][C:32]=3[C:33](=[O:34])[NH2:35])[CH:21]=2)=[CH:17][CH:16]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 89484414HCID 89484414, compound

Product 1

HCID 90308749HCID 90308749, compound

Procedure

An excessive quantity of m-CPBA was used, and a method similar to that in Example 1 (Step 3) and (Step 4), a method according to these methods, or a combination of them with routine procedures was used for 3-(methylthio)-5-(5-(5-acetylthiophen-2-yl)pyridin-3-ylamino)-1,2,4-triazine-6-carboxamide obtained in Example 15 to obtain the titled compound as a white solid.

Sources & evidence

ORD record
ord-98c16802b1154b4ba44c577ad6fac300
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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