反应详情

Acetone (1.0 mL) and tert-butoxy potassium (2.7 g) were added to a solution of 3-nitroaniline (1.38 g) in dimethylsulfoxide (20 ml), and the reaction solution was stirred at room temperature for 3 hours. The reaction solution was diluted with ethyl acetate, and washed successively with an aqueous ammonium chloride solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate) to obtain 2-methyl-4-nitro-1H-indole.

1. washwashed successively with an aqueous ammonium chloride solution
2. dry with materialAfter drying over anhydrous sodium sulfate
3. customthe solvent was evaporated under vacuum
4. customThe residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate)