1,4-Dioxane hydrochloride → HCID 90309404, compound

HRID 2283700Notes

Reaction equation

HRID 2283700 reaction equation
C(OC(=O)[NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:12]=1)(C)(C)C.[ClH:20].O1CCOCC1>>[ClH:20].[N:14]1[CH:15]=[CH:16][CH:17]=[N:18][C:13]=1[C:11]1[CH:12]=[C:8]([NH2:7])[S:9][CH:10]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 131733529HCID 131733529, compound

Product 1

HCID 90309404HCID 90309404, compound

Procedure

A 4 N hydrochloric acid-dioxane solution (20 mL) was added to tert-butyl(4-(pyrimidin-2-yl)thiophen-2-yl)carbamate obtained in the above-described Step 3, and the reaction solution was stirred at room temperature for 2 hours. The solvent was evaporated under vacuum, and then isopropyl ether was added. The deposited precipitate was filtrated to obtain 4-(pyrimidin-2-yl)thiophen-2-amine hydrochloride.

Workup

  1. customobtained in the above-described Step 3
  2. customThe solvent was evaporated under vacuum
  3. additionisopropyl ether was added
  4. filtrationThe deposited precipitate was filtrated

Sources & evidence

ORD record
ord-b84e013cd56f45cc86b02ca6b52a50b6
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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