1,4-Dioxane hydrochloride → HCID 90309404, compound

Participants

Reaction Steps

A 4 N hydrochloric acid-dioxane solution (20 mL) was added to tert-butyl(4-(pyrimidin-2-yl)thiophen-2-yl)carbamate obtained in the above-described Step 3, and the reaction solution was stirred at room temperature for 2 hours. The solvent was evaporated under vacuum, and then isopropyl ether was added. The deposited precipitate was filtrated to obtain 4-(pyrimidin-2-yl)thiophen-2-amine hydrochloride.

Provenance & Evidence