HCID 90308924, compound → HCID 90309031, compound

HRID 2283706Notes

Reaction equation

HRID 2283706 reaction equation
[CH:1]1([C:4]2[C:12]3[C:8](=[CH:9][N:10]([CH3:13])[N:11]=3)[CH:7]=[C:6]([N+:14]([O-])=O)[CH:5]=2)[CH2:3][CH2:2]1>[Pd].C(OCC)(=O)C>[CH:1]1([C:4]2[C:12]3[C:8](=[CH:9][N:10]([CH3:13])[N:11]=3)[CH:7]=[C:6]([NH2:14])[CH:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 90308924HCID 90308924, compound

Product 1

HCID 90309031HCID 90309031, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Palladium on carbon (300 mg) was added to a solution of 7-cyclopropyl-2-methyl-5-nitro-2H-indazole obtained in the above-described Step 1 (311 mg) in ethyl acetate (5 mL) under nitrogen atmosphere, and the reaction solution was stirred under hydrogen atmosphere at room temperature overnight. The insolubles were filtrated, then the solvent was evaporated under vacuum, and the resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate) to obtain 7-cyclopropyl-2-methyl-2H-indazol-5-amine as brown amorphous.

Workup

  1. filtrationThe insolubles were filtrated
  2. customthe solvent was evaporated under vacuum
  3. customthe resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate)

Sources & evidence

ORD record
ord-5d11678971784e2ab1b515fd5fc789ae
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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