Iodoethane → 1-Ethyl-1H-indazol-4-amine

HRID 2283714Notes

Reaction equation

[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][NH:8]2)([O-])=O.I[CH2:14][CH3:15]>>[CH2:14]([N:8]1[C:9]2[CH:10]=[CH:11][CH:12]=[C:4]([NH2:1])[C:5]=2[CH:6]=[N:7]1)[CH3:15]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 180574-Nitroindazole

Product 1

HCID 696748031-Ethyl-1H-indazol-4-amine

Procedure

In accordance with Example 68 (Step 2), 4-nitro-1H-indazole was used instead of 4-nitro-1H-indole, and iodoethane was used instead of (S)-tetrahydrofuran-3-yl methanesulfonate to obtain 1-ethyl-1H-indazol-4-amine.

Sources & evidence

ORD record: ord-d64868e8c82f4da7b4525752ed10b63b
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09145414B2

Reaction notes

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