1,4-Dioxane hydrochloride → HCID 90308838, compound

HRID 2283717Notes

Reaction equation

HRID 2283717 reaction equation
[ClH:1].O1CCOCC1.C(OC(=O)[NH:14][C:15]1[CH:19]=[C:18]([C:20]2[N:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[S:17][CH:16]=1)(C)(C)C>>[ClH:1].[N:21]1[CH:22]=[CH:23][CH:24]=[N:25][C:20]=1[C:18]1[S:17][CH:16]=[C:15]([NH2:14])[CH:19]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 131733530HCID 131733530, compound

Product 1

HCID 90308838HCID 90308838, compound

Procedure

A 4 N hydrochloric acid-dioxane solution (8 mL) was added to tert-butyl(5-(pyrimidin-2-yl)thiophen-3-yl)carbamate obtained in the above-described Step (544 mg), and the reaction solution was stirred at room temperature for 90 minutes. The solvent was evaporated under vacuum to obtain 5-(pyrimidin-2-yl)thiophen-3-amine hydrochloride as a brown solid.

Workup

  1. customobtained in the above-described Step (544 mg)
  2. customThe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-aec8e9d4b366408eb44b3c8bf685e0a6
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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