1,4-Dioxane hydrochloride → HCID 90308838, compound

Participants

Reaction Steps

A 4 N hydrochloric acid-dioxane solution (8 mL) was added to tert-butyl(5-(pyrimidin-2-yl)thiophen-3-yl)carbamate obtained in the above-described Step (544 mg), and the reaction solution was stirred at room temperature for 90 minutes. The solvent was evaporated under vacuum to obtain 5-(pyrimidin-2-yl)thiophen-3-amine hydrochloride as a brown solid.

Provenance & Evidence