Tetrahydro-4H-pyran-4-ol → HCID 90309382, compound

HRID 2283723Notes

Reaction equation

HRID 2283723 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4](O)[CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[CH:14][NH:15]2)=[C:11]([N+:18]([O-])=O)[CH:10]=1>>[CH3:8][C:9]1[CH:10]=[C:11]([NH2:18])[C:12]2[CH:13]=[CH:14][N:15]([CH:4]3[CH2:5][CH2:6][O:1][CH2:2][CH2:3]3)[C:16]=2[CH:17]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 247287646-Methyl-4-nitro-1H-indole

Product 1

HCID 90309382HCID 90309382, compound

Procedure

In accordance with Example 68 (Steps 1 and 2), tetrahydro-2H-pyran-4-ol was used instead of (S)-tetrahydrofuran-3-ol, and 6-methyl-4-nitro-1H-indole was used instead of 4-nitro-1H-indole to obtain 6-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-indol-4-amine.

Sources & evidence

ORD record
ord-8cdc040858674a18a1d4805538ceb574
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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