反应详情

温度

40 °C

A mixture of 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine (600.00 mg; 1.83 mmol; 1.0 eq.), 4-amino-6-chloropyrimidine-5-carbaldehyde (303.25 mg; 1.92 mmol; 1.05 eq.), DIEA (0.95 ml; 5.5 mmol; 3.0 eq.) in acetonitrile (10.0 ml) was heated at 40° C. for 1 h. The reaction mixture was poured into water. The precipitate was filtered, washed with water and dried under vacuum to afford the title compound in 85% yield. LC-MS: (M+1=449, obsd.=449).

1. filtrationThe precipitate was filtered
2. washwashed with water
3. customdried under vacuum