反应详情

The reaction mixture of 6-chloro-5-ethyl-pyrimidin-4-ylamine (50.00 mg; 0.32 mmol; 1.00 eq.), 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(3-fluoroazetidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine (138.05 mg; 0.33 mmol; 1.05 eq.) and DIEA (65.77 mg; 0.48 mmol; 1.50 eq.) in DMSO (1.5 ml) was placed in microwave at 125° C. for 1 hr. found small amount desired, mostly was sm, 140° C. for another 1 hr, more product formed, 150° C. for another 1 hr, purified the product by HPLC, collected title compound 33 mg, yield 16%. LC-MS (M+1=536, obsd.=536).

1. waitmostly was sm, 140° C. for another 1 hr
2. custommore product formed, 150° C. for another 1 hr
3. custompurified the product by HPLC