HRID2284021

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78721

6-Chloro-5-methoxypyrimidin-4-amine

C5H6ClN3O

结构：CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1

HCID71516690

未命名化合物

PRODUCTS

生成物

结构：COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1

HCID89442481

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-isopropoxypyrimidin-4-amine using 6-chloro-5-methoxypyrimidin-4-amine

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-688fd139356b4abf9dd4c0e5e7479b97
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09145392B2
来源说明: uspto-grants-2015_09

反应 SMILES

[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:13]=3)[N:9]=[C:8]2[CH:23]2[CH2:28][CH2:27][N:26]([C:29]3[N:34]=[CH:33][N:32]=[C:31]([NH2:35])[C:30]=3[O:36][CH:37](C)C)[CH2:25][CH2:24]2)[CH2:4][CH2:3][CH2:2]1.ClC1N=CN=C(N)C=1OC>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19]([F:22])([F:20])[F:21])[CH:13]=3)[N:9]=[C:8]2[CH:23]2[CH2:28][CH2:27][N:26]([C:29]3[N:34]=[CH:33][N:32]=[C:31]([NH2:35])[C:30]=3[O:36][CH3:37])[CH2:25][CH2:24]2)[CH2:2][CH2:3][CH2:4]1