6-Chloro-5-methoxypyrimidin-4-amine → 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methoxypyrimidin-4-amine

HRID 2284021Notes

Reaction equation

HRID 2284021 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:13]=3)[N:9]=[C:8]2[CH:23]2[CH2:28][CH2:27][N:26]([C:29]3[N:34]=[CH:33][N:32]=[C:31]([NH2:35])[C:30]=3[O:36][CH:37](C)C)[CH2:25][CH2:24]2)[CH2:4][CH2:3][CH2:2]1.ClC1N=CN=C(N)C=1OC>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([C:19]([F:22])([F:20])[F:21])[CH:13]=3)[N:9]=[C:8]2[CH:23]2[CH2:28][CH2:27][N:26]([C:29]3[N:34]=[CH:33][N:32]=[C:31]([NH2:35])[C:30]=3[O:36][CH3:37])[CH2:25][CH2:24]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 787216-Chloro-5-methoxypyrimidin-4-amineHCID 71516690HCID 71516690, compound

Product 1

HCID 894424816-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methoxypyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-isopropoxypyrimidin-4-amine using 6-chloro-5-methoxypyrimidin-4-amine

Sources & evidence

ORD record
ord-688fd139356b4abf9dd4c0e5e7479b97
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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