HRID2284026
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A reaction mixture of 6-Chloro-5-ethoxy-pyrimidin-4-ylamine (30.00 mg; 0.17 mmol; 1.00 eq.), 4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine trifluoroacetate (2) (107.92 mg; 0.17 mmol; 1.00 eq.), and Cs2CO3 (225.22 mg; 0.69 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for overnight. Purified the product by prep HPLC, collected title compound 27 mg, yield 24%. LC-MS: (M+1=534, obsd.=534).
WORKUP
后处理
- customPurified the product by prep HPLC