Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6-Chloro-5-ethoxypyrimidin-4-amine | HCID 73555047 | — |
| Reactant | 4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine trifluoroacetate | HCID 89442764 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89450705 | HCID 89450705 | 29.8% |
Reaction Steps
A reaction mixture of 6-Chloro-5-ethoxy-pyrimidin-4-ylamine (30.00 mg; 0.17 mmol; 1.00 eq.), 4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine trifluoroacetate (2) (107.92 mg; 0.17 mmol; 1.00 eq.), and Cs2CO3 (225.22 mg; 0.69 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for overnight. Purified the product by prep HPLC, collected title compound 27 mg, yield 24%. LC-MS: (M+1=534, obsd.=534).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09145392B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-cfeba50e0fa14d1ba5765130318b6a04 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
