HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 89442612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
| Reactant | 4-Amino-6-chloropyrimidin-5-ol | HCID 13012885 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 89442612 | HCID 89442612 | 78% |
Reaction Steps
A reaction mixture of 4-Amino-6-chloro-pyrimidin-5-ol (500.00 mg; 3.44 mmol; 1.00 eq.), Cs2CO3 (1343.15 mg; 4.12 mmol; 1.20 eq.), and Trifluoro-methanesulfonic acid 2,2,2-trifluoro-ethyl ester (0.59 ml; 4.12 mmol; 1.20 eq.) in DMF 2 ml was stirred at RT for overnight. lc-ms showed clean desired, worked up, purified by HPLC, collected title compound 610 mg, yield 78%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145392B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-89605729c1fb41e39199ddcb29122729 |
| Source note | uspto-grants-2015_09 |