反应详情

A reaction mixture of 4-Amino-6-chloro-pyrimidin-5-ol (500.00 mg; 3.44 mmol; 1.00 eq.), Cs2CO3 (1343.15 mg; 4.12 mmol; 1.20 eq.), and Trifluoro-methanesulfonic acid 2,2,2-trifluoro-ethyl ester (0.59 ml; 4.12 mmol; 1.20 eq.) in DMF 2 ml was stirred at RT for overnight. lc-ms showed clean desired, worked up, purified by HPLC, collected title compound 610 mg, yield 78%.

1. custompurified by HPLC