HRID2284046
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 80 °C
PROCEDURE
实验过程
A reaction mixture of 5-Bromo-6-chloro-pyrimidin-4-ylamine (53.00 mg; 0.25 mmol; 1.00 eq.), 4-[1-(2-azetidin-1-yl-ethyl)-2-piperidin-4-yl-1H-imidazol-4-yl]-2-trifluoromethyl-pyridine hydrochloride (4) (133.56 mg; 0.25 mmol; 1.00 eq.), and ethyl-diisopropyl-amine (0.23 ml; 1.27 mmol; 5.00 eq.) in ACN 3 ml was stirred at 80° C. for overnight. Purified by HPLC (basic), collected title compound, 30 mg, yield, 21%. LC-MS: (M+1=551, obsd.=551).
WORKUP
后处理
- customPurified by HPLC (basic)
- customcollected title compound, 30 mg
- customyield