Hydrochloric Acid → HCID 89442752, compound

HRID 2284054Notes

Reaction equation

HRID 2284054 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:15]([CH2:27][CH2:28][OH:29])[CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[C:21]([CH3:26])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30].O1CCOCC1>CO>[ClH:30].[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:18]=[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:15]([CH2:27][CH2:28][OH:29])[CH:16]=2)=[CH:20][C:21]=1[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 89442483HCID 89442483, compound

Product 1

HCID 89442752HCID 89442752, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-[4-(4-Fluoro-3-methyl-phenyl)-1-(2-hydroxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (1600.00 mg; 3.97 mmol; 1.00 eq.) in methanol 10 ml added 4.0M HCl in dioxane (9.91 ml; 39.65 mmol; 10.00 eq.), the reaction mixture was stirred at RT for 3 hrs, lc-ms showed clean desired, removed off solvent, got white solid as title compound.

Workup

  1. customremoved off solvent

Sources & evidence

ORD record
ord-6ea9c7a711874f1e9fe4c0e4e008fe0c
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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