Benzenamine, 4-(4-morpholinyl)- → HCID 178522194, compound

HRID 2284230Notes

Reaction equation

HRID 2284230 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[F:14][C:15]([F:42])([F:41])[CH2:16][N:17](CC(F)(F)F)[C:18]1[CH:35]=[CH:34][C:21]2[NH:22][C:23]([C:25]3[CH:33]=[CH:32][C:28]([C:29]([O-])=[O:30])=[CH:27][CH:26]=3)=[N:24][C:20]=2[CH:19]=1>>[F:42][C:15]([F:14])([F:41])[CH2:16][NH:17][C:18]1[CH:35]=[CH:34][C:21]2[NH:22][C:23]([C:25]3[CH:33]=[CH:32][C:28]([C:29]([NH:11][C:10]4[CH:12]=[CH:13][C:7]([N:4]5[CH2:3][CH2:2][O:1][CH2:6][CH2:5]5)=[CH:8][CH:9]=4)=[O:30])=[CH:27][CH:26]=3)=[N:24][C:20]=2[CH:19]=1

Participants

3

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 178524235HCID 178524235, compound

Product 1

HCID 178522194HCID 178522194, compound

Procedure

Compound 455 was prepared from 4-morpholinoaniline and 4-(5-bis(2,2,2-trifluoroethyl)amino-1H-benzimidazol-2-yl)benzoate by standard conditions. [M+H]+ calcd for C26H24F3N5O2: 496.19; found: 496.02.

Sources & evidence

ORD record
ord-fa2331c4dfe5437caf5b3b1ce7786e85
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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