4-(4-Hydroxy-1-piperidinyl)benzoic acid → N-(4-((4-Amino-2-fluorophenyl)amino)phenyl)-4-(4-hydroxypiperidin-1-yl)benzamide

HRID 2284304Notes

Reaction equation

HRID 2284304 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[F:16])=[CH:4][CH:3]=1.[OH:17][CH:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1>>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:28](=[O:29])[C:27]3[CH:26]=[CH:25][C:24]([N:21]4[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]4)=[CH:32][CH:31]=3)=[CH:7][CH:6]=2)=[C:10]([F:16])[CH:11]=1

Participants

3

Reactant 2

HCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 86674024N1-(4-aminophenyl)-2-fluorobenzene-1,4-diamine

Product 1

HCID 67112608N-(4-((4-Amino-2-fluorophenyl)amino)phenyl)-4-(4-hydroxypiperidin-1-yl)benzamide

Procedure

Compound 807 was prepared according to the procedure described in Scheme IV from N1-(4-aminophenyl)-2-fluorobenzene-1,4-diamine and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C24H25FN4O2: 421.20; found 420.98.

Sources & evidence

ORD record
ord-bf4e0f0849764032ad1a07aa2851b491
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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