4-(4-Hydroxy-1-piperidinyl)benzoic acid → N-(3-Chloro-4-((4-(4-(4-hydroxypiperidin-1-yl)benzamido)phenyl)amino)phenyl)-4-(4-hydroxypiperidin-1-yl)benzamide

HRID 2284305Notes

Reaction equation

HRID 2284305 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[Cl:16])=[CH:4][CH:3]=1.[OH:17][CH:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1>>[Cl:16][C:10]1[CH:11]=[C:12]([NH:15][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([N:21]3[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]3)=[CH:25][CH:26]=2)[CH:13]=[CH:14][C:9]=1[NH:8][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:28](=[O:29])[C:27]2[CH:26]=[CH:25][C:24]([N:21]3[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]3)=[CH:32][CH:31]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 86674025N1-(4-aminophenyl)-2-chlorobenzene-1,4-diamine

Product 1

HCID 67114493N-(3-Chloro-4-((4-(4-(4-hydroxypiperidin-1-yl)benzamido)phenyl)amino)phenyl)-4-(4-hydroxypiperidin-1-yl)benzamide

Procedure

Compound 826 was prepared according to the procedure described in Scheme IV from N1-(4-aminophenyl)-2-chlorobenzene-1,4-diamine and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C36H38ClN5O4: 640.26; found 640.12.

Sources & evidence

ORD record
ord-430be2ee5c414454a11e85572752cd1c
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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